Neuropeptide Y Receptor

Neuropeptide Y Receptor Related Products (132):

By Effects:	Inhibitors (14) Agonists (50) Antagonists (38) Activator (1) Modulators (4) Control (1)

Cat. No.	Product Name	Effect	Purity

HY-P3212

Allo-aca	Antagonist	99.82%
Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

HY-P0198

Neuropeptide Y (human,rat,mouse)		99.94%
Neuropeptide Y (human,rat,mouse) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P1514

Peptide YY (PYY), human		99.17%
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.

HY-P0198A

Neuropeptide Y (human,rat,mouse) TFA		99.28%
Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P1127

Galanin (1-30), human	Agonist	99.91%
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with K_is of both 1 nM.

HY-186035

R06039-636	Agonist
R06039-636 is an agonist of the Neuropeptide S receptor (NPSR) with an EC₅₀ value of 94nM.

HY-P992230

Anti-Galanin Antibody
Anti-Galanin Antibody is a monoclonal antibody that targets galanin. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-Galanin Antibody, please refer to Human IgG2 kappa, Isotype Control (HY-P99002).

HY-P11411

[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat
[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat is a fragment analogue of a neuropeptide Y (NPY) with cardiovascular activity. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can induce profound and sustained hypotension in both hypertensive and normotensive rats and its antihypertensive effect is partly attributed to its activity on histamine receptor. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can be used for studying antihypertensive effects.

HY-P1130

M871	Antagonist	99.98%
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits K_i values of 13.1 nM, 420 nM and >10 μM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain).

HY-14450

JNJ-31020028	Antagonist	98.07%
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC₅₀ values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.

HY-100717

HT-2157	Antagonist	98.0%
HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal₃).

HY-P1601

Neuropeptide Y(29-64)		99.85%
Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

HY-P1723

Spexin	Agonist	99.12%
Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy.

HY-P1135

M1145	Agonist	99.96%
M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a K_i of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (K_i=587 nM) and a 76-fold higher affinity over GalR3 (K_i=497 nM). M1145 has an additive effect on the signal transduction of galanin.

HY-P1131

M617	Agonist	99.54%
M617 is a selective galanin receptor 1 (GAL1) agonist, with K_is of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats.

HY-P1132A

Galanin (1-29)(rat, mouse) TFA	Agonist	99.83%
Galanin (1-29)(rat, mouse) TFA is a non-selective galanin receptor agonist, with K_is of 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3, respectively. Anticonvulsant effect.

HY-P0199

Pancreatic Polypeptide, human	Agonist	99.39%
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-P1021A

Peptide YY (PYY) (3-36), porcine TFA	Agonist	99.97%
Peptide YY (PYY) (3-36), porcine TFA is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

HY-P1305

CART(55-102)(rat)		99.03%
CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior.

HY-P990631

Mibavademab	Inhibitor	≥99.0%
Mibavademab is a CHO-expressed humanized antibody that targets LEPR/CD295. Mibavademab is equipped with a huIgG4SP heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.58 kDa. The isotype control for Mibavademab can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

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